Menthol sensory qualities and smoking topography: a review of tobacco industry documents.

ObjectiveTo determine what the tobacco industry knew about the potential effects of menthol on smoking topography-how a person smokes a cigarette.MethodsA snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) between 1 June 2010 and 9 August 2010. We qualitatively analysed a final collection of 252 documents related to menthol and smoking topography.ResultsThe tobacco industry knew that menthol has cooling, anaesthetic and analgesic properties that moderate the harshness and irritation of tobacco. Owing to its physiological effects, menthol contributes to the sensory qualities of the smoke and affects smoking topography and cigarette preference.ConclusionOur review of industry studies suggests that the amount of menthol in a cigarette is associated with how the cigarette is smoked and how satisfying it is to the smoker. If menthol in cigarettes was banned, as the US Food and Drug Administration (FDA) is currently considering, new/experimental smokers might choose not to smoke rather than experience the harshness of tobacco smoke and the irritating qualities of nicotine. Similarly, established menthol smokers might choose to quit if faced with an unpleasant smoking alternative

High strength, wire-reinforced electroformed structures

Using half-round reinforcing wires, electrodeposited matrix metal readily fills spaces between wires in intimate contact with wires and without voids. Procedure combines advantages of electroforming with high-strength of commonly available wire to produce non-welded shell structures for high pressure uses

The Fallacy of Mandating Contraceptive Equity: Why Laws That Protect Women with Health Insurance Deepen Institutional Discrimination

This Comment takes a close look at the United States\u27 approach to health insurance and various unsuccessful efforts at broadening the health care choices of American women in the form of contraceptive equity laws

Context-specific adaptation of vertical vergence to correlates of eye position

AbstractVertical phoria (vertical vergence in the absence of binocular feedback) can be trained to vary with non-visual cues such as vertical conjugate eye position, horizontal conjugate eye position and horizontal vergence. These prior studies demonstrated a low-level association or coupling between vertical vergence and several oculomotor cues. As a test of the potential independence of multiple eye-position cues for vertical vergence, context-specific adaptation experiments were conducted in three orthogonal adapting planes (midsagittal, frontoparallel, and transverse). Four vertical disparities in each of these planes were associated with various combinations of two specific components of eye position. Vertical disparities in the midsagittal plane were associated with horizontal vergence and vertical conjugate eye position; vertical disparities in the frontoparallel plane were associated with horizontal and vertical conjugate eye position; and vertical disparities in the transverse plane were associated with horizontal vergence and horizontal conjugate eye position. The results demonstrate that vertical vergence can be adapted to respond to specific combinations of two different sources of eye-position information. The results are modeled with an association matrix whose inputs are two classes of eye position and whose weighted output is vertical vergence

Operations management system

The objective of an operations management system is to provide an orderly and efficient method to operate and maintain aerospace vehicles. Concepts are described for an operations management system and the key technologies are highlighted which will be required if this capability is brought to fruition. Without this automation and decision aiding capability, the growing complexity of avionics will result in an unmanageable workload for the operator, ultimately threatening mission success or survivability of the aircraft or space system. The key technologies include expert system application to operational tasks such as replanning, equipment diagnostics and checkout, global system management, and advanced man machine interfaces. The economical development of operations management systems, which are largely software, will require advancements in other technological areas such as software engineering and computer hardware

Structural and Physical Properties of CaFe4As3 Single Crystals

We report the synthesis, and structural and physical properties of CaFe4As3 single crystals. Needle-like single crystals of CaFe4As3 were grown out of Sn flux and the compound adopts an orthorhombic structure as determined by X-ray diffraction measurements. Electrical, magnetic, and thermal properties indicate that the system undergoes two successive phase transitions occurring at TN1 ~ 90 K and TN2 ~ 26 K. At TN1, electrical resistivities (\rho(b) and \rho(ac)) are enhanced while magnetic susceptibilities (\chi(b) and \chi(ac)) are reduced in both directions parallel and perpendicular to the b-axis, consistent with the scenario of antiferromagnetic spin-density-wave formation. At TN2, specific heat reveals a slope change, and \chi(ac) decreases sharply but \chi(b) has a clear jump before it decreases again with decreasing temperature. Remarkably, both \rho(b) and \rho(ac) decrease sharply with thermal hysteresis, indicating the first-order nature of the phase transition at TN2. At low temperatures, \rho(b) and \rho(ac) can be described by {\rho} = {\rho}0 + AT^\alpha ({\rho}0, A, and {\alpha} are constants). Interestingly, these constants vary with applied magnetic field. The ground state of CaFe4As3 is discussed.Comment: 15 pages, 8 figures, Submitted to Physical Review

High resolution mapping of Puget Sound shorelines

In an effort to collect high-resolution baseline coastal topographic data of beaches and bluffs around the Puget Sound and Strait of Juan de Fuca, the Washington State Department of Ecology Coastal Monitoring & Analysis Program (CMAP) conducted a series of boat-based lidar surveys in October 2013, May through September 2015, and May 2016 at a total of 16 sites spanning 220 km of shoreline and over two dozen drift cells. The drift cells were selected based on a rigorous and systematic geospatial analysis of bluff-backed beaches for their potential for significant bluff sediment supply to intact shorelines identified as having a relative abundance of habitat for forage fish, eelgrass, herring, shellfish, and geoduck, as well as having previous investments in beach restoration projects, and potential for future shoreline armoring and habitat loss based on population growth scenarios. As such, the surveyed drift cells are top candidates for implementing drift cell-scale protection and restoration strategies. The boat-based lidar and GPS topography data were used to produce 0.5-m digital elevation models (DEMs) for the beaches and bluffs at each of the survey sites. These DEMs provide the opportunity to inventory and characterize the shoreline landscape that affects nearshore ecosystem services such as feeder bluff activity, beach slope and width, and the position, length, and elevation of armoring relative to the backshore. Boat-based lidar provides an advantageous point of view of the bluff face, resulting in high resolution data which is needed to gain insight into bluff failure and erosion mechanisms and corresponding sediment transport processes. In addition, it successfully collects data under overhanging vegetation and overwater structures. Repeat surveys in the future would enable change analyses for quantifying bluff sediment supply, changes in marine riparian vegetation, and a better understanding of the linkages between physical and ecological processes

Evaluating methods to obtain high resolution nearshore bathymetry and coastal topography for Puget Sound

The Washington State Department of Ecology Coastal Monitoring & Analysis Program performed a coastal topographic and bathymetric survey of Port Gamble Bay between March 9 and March 28, 2014. Boat-based topographic lidar was collected along the shoreline of the bay and multibeam bathymetric sonar was collected throughout the bay to obtain a seamless topographic-bathymetric surface with complete coverage of Port Gamble Bay. The survey was performed with a R2Sonic 2022 multibeam echosounder, an Optech ILRIS-HD-ER mobile laser scanner, and an Applanix POS MV 320 v5 receiving real-time kinematic positioning corrections. The Joint Airborne Lidar Bathymetry Technical Center of Expertise (JALBTCX) performed a topographic and bathymetric lidar survey of Port Gamble Bay on September 4, 2014. The Coastal Zone Mapping and Imaging Lidar (CZMIL) system was used to obtain seamless coastal topographic-bathymetric coastal intertidal and nearshore coverage of Port Gamble Bay. The bathymetric depth coverage is limited to laser extinction, which is determined by water clarity. The availability of these two datasets provides the unique opportunity to compare data between high-resolution boat-based lidar and multibeam systems and the state-of-the-art airborne topo-bathy lidar system and also assess detection and resolution of specific features throughout a range of water depths across the nearshore important to habitat and restoration efforts. This effort provides a detailed comparison of coverage and resolution of nearshore features and will help clarify differences between these capabilities to aid in planning complementary efforts in coastal zone mapping and monitoring